When chronic irritation occurs around the median nerve, it becomes
coompressed and is continually pushed against the ligament above it. When the
nerve is continually constricted, it can become compressed to the point that it
begins to deteriorate. This results in a slowing of nerve impulses, which may
cause a loss of feeling in the fingers and a loss of strength and coordination
at the base of the thumb. If the condition is not treated, it could result in
permanent deterioration of muscle tissue and function.